Short-Chain Fructo-oligosaccharides Reduce the Occurrence of Colon Tumors and Develop Gut-associated Lymphoid Tissue in Miii Mice'

CS7BLI6J-MinI+ mice, which are heterozygous for a non-sense muta tion in the Apc gene, provide a model for both familial adenomatous polyposisand sporadic colon cancers.In our study, gut tumors and small Intestine lymphoid nodules were counted in Mm mice fed fiber-enriched diets for 6 weeks.Neither starch-free wheat bran nor resistant starch modified the number of tumors. However,short-chain fructo-ollgosaccha ridesdramaticallyreducedthe incidenceof colontumorsand concomi tantly developed gut-associated lymphoid tissue. Our experiment shows that short-chain fructo-oligosaccharldes counteract advanced stages of colon carcinogenesis, possibly via stimulation ofantitunsoral immunity by modulationof the colonicecosystem.